In this joint submission, we examine the Government of South Africa’s human rights record since its third-cycle universal periodic review (UPR) in 2017. Specifically, we assess the government’s fulfilment of adolescent and youth sexual and reproductive health and rights. To this end, we analyse South Africa’s implementation of recommendations received relating to these issues and provide specific, action-orientated follow-up recommendations at the conclusion of this submission. Between the 9th and 10th of March 2022, 15 youth led, serving and focused organizations in South Africa convened in person and virtually to deliberate on how COVID-19 has affected the HIV, SRHR and GBV/F outcomes of adolescents and young people in their diversity.